Podrobnosti záznamu

Název
    The structure and material composition of ossified aortic valves identified using a set of scientific methods
Autor
    Coufalová, L.
    Havelcová, Martina
    Hynek, R.
    Kučková, S.
    Šmíd, M.
    Velčovská, M.
    Zeman, Antonín
Jazyk
    anglicky
Typ dokumentu
    článek v odborném periodiku
Zdrojový dokument - seriál
    Journal of Asian Earth Sciences
Svazek/č.
    Roč. 77, November
Strany
    s. 311-317
Rok
    2013
Poznámky
    Autoři celkem: 7
    Projekt: GA205/09/1162, GA ČR, CZ3cav_un_auth*0254057
    Rozsah: 7 s. : E
Předmětová kategorie
    aortic stenosis
    cholesterol
    degenerative (calcification-sclerotic) changes
    hydroxyapatite
    proteins
Klíčové slovo
    Aortic
    Composition
    Identified
    Material
    Methods
    Ossified
    Scientific
    Set
    Structure
    Using
    Valves
Abstrakt (anglicky)
   Degenerative aortic stenosis has become a common and dangerous disease in recent decades. This disease leads to the mineralization of aortic valves, their gradual thickening and loss of functionality. We studied the detailed assessment of the proportion and composition of inorganic and organic components in the ossified aortic valve, using a set of analytical methods applied in science: polarized light microscopy, scanning electron microscopy, X-ray fluorescence, X-ray diffraction, gas chromatography/mass spectrometry and liquid chromatography-tandem mass spectrometry. The sample valves showed the occurrence of phosphorus and calcium in the form of phosphate and calcium carbonate, hydroxyapatite, fluorapatite and hydroxy-fluorapatite, with varying content of inorganic components from 65 to 90 wt%, and with phased development of degenerative disability. The outer layers of the plaque contained an organic component with peptide bonds, fatty acids, proteins and cholesterol.
Přispěvatel
    AV ČR Brno, Ústav struktury minerálů a hornin
Kód přispěvatele
    AV ČR, ÚSMH
Zdrojový formát
    U
Datum importu
    24. 10. 2014