Podrobnosti záznamu

Název
    Biological Evaluation of Polydimethylsiloxane Modified by Calcium Phosphate Nanoparticles for Potential Application in Spine Surgery
Autor
    Bačáková, Lucie
    Balík, Karel
    Filová, Elena
    Havlíková, Jana
    Martynková, G.S.
    Rýglová, Šárka
    Smetana, K.
    Sucharda, Zbyněk
    Suchý, Tomáš
    Šupová, Monika
Jazyk
    anglicky
Typ dokumentu
    článek v odborném periodiku
Zdrojový dokument - seriál
    Science of Advanced Materials
Svazek/č.
    Roč. 5, č. 5
Strany
    s. 484-493
Rok
    2013
Poznámky
    Projekt: FT-TA3/131, GA MPO3cav_un_auth*0217614
    Projekt: GA106/09/1000, GA ČR, CZ3cav_un_auth*0253154
    Rozsah: 10 s. : P
Předmětová kategorie
    Biomaterials
    Ceramics
    Composite Materials
    Polymers
Klíčové slovo
    Application
    Biological
    Calcium
    Evaluation
    Modified
    Nanoparticles
    Phosphate
    Polydimethylsiloxane
    Potential
    Spine
    Surgery
Abstrakt (anglicky)
   The biological properties of a composite made of polydimethylsiloxane matrix and two kinds of calcium phosphate nanoparticles (hydroxyapatite, beta tricalcium phosphate) were tested by means of in vitro and in vivo investigations. Chemical and phase analyses of the nanoparticles were performed. The effects of different volume fractions of nanoparticles were investigated. Human osteoblast-like cell cultures (MG 63) demonstrated that the addition of 5-15 vol.% of nanoparticles had a significantly positive effect on osteoblast viability, and that high concentration did not support cell proliferation. The highest rates of osteointegration in pig bone were attained for implants modified by 15 vol.% hydroxyapatite and more intensive formation of new bone tissue was observed. Our study indicates that hydroxyapatite probably better imitates the composition and structure of the mineral phase of real bone.
Přispěvatel
    AV ČR Brno, Ústav struktury minerálů a hornin
Kód přispěvatele
    AV ČR, ÚSMH
Zdrojový formát
    U
Datum importu
    24. 10. 2014