Record details

Title
    The structure and material composition of ossified aortic valves identified using a set of scientific methods
Author
    Coufalová, L.
    Havelcová, Martina
    Hynek, R.
    Kučková, S.
    Šmíd, M.
    Velčovská, M.
    Zeman, Antonín
Language
    anglicky
Publication type
    článek v odborném periodiku
Source title - serial
    Journal of Asian Earth Sciences
Vol./nr.
    Roč. 77, November
Pages
    s. 311-317
Year
    2013
Notes
    Autoři celkem: 7
    Projekt: GA205/09/1162, GA ČR, CZ3cav_un_auth*0254057
    Rozsah: 7 s. : E
Subject category
    aortic stenosis
    cholesterol
    degenerative (calcification-sclerotic) changes
    hydroxyapatite
    proteins
Keyword
    Aortic
    Composition
    Identified
    Material
    Methods
    Ossified
    Scientific
    Set
    Structure
    Using
    Valves
Abstract (in english)
   Degenerative aortic stenosis has become a common and dangerous disease in recent decades. This disease leads to the mineralization of aortic valves, their gradual thickening and loss of functionality. We studied the detailed assessment of the proportion and composition of inorganic and organic components in the ossified aortic valve, using a set of analytical methods applied in science: polarized light microscopy, scanning electron microscopy, X-ray fluorescence, X-ray diffraction, gas chromatography/mass spectrometry and liquid chromatography-tandem mass spectrometry. The sample valves showed the occurrence of phosphorus and calcium in the form of phosphate and calcium carbonate, hydroxyapatite, fluorapatite and hydroxy-fluorapatite, with varying content of inorganic components from 65 to 90 wt%, and with phased development of degenerative disability. The outer layers of the plaque contained an organic component with peptide bonds, fatty acids, proteins and cholesterol.
Contributor
    AV ČR Brno, Ústav struktury minerálů a hornin
Contributor code
    AV ČR, ÚSMH
Source format
    U
Import date
    24. 10. 2014