Record details

Title
    Biological Evaluation of Polydimethylsiloxane Modified by Calcium Phosphate Nanoparticles for Potential Application in Spine Surgery
Author
    Bačáková, Lucie
    Balík, Karel
    Filová, Elena
    Havlíková, Jana
    Martynková, G.S.
    Rýglová, Šárka
    Smetana, K.
    Sucharda, Zbyněk
    Suchý, Tomáš
    Šupová, Monika
Language
    anglicky
Publication type
    článek v odborném periodiku
Source title - serial
    Science of Advanced Materials
Vol./nr.
    Roč. 5, č. 5
Pages
    s. 484-493
Year
    2013
Notes
    Projekt: FT-TA3/131, GA MPO3cav_un_auth*0217614
    Projekt: GA106/09/1000, GA ČR, CZ3cav_un_auth*0253154
    Rozsah: 10 s. : P
Subject category
    Biomaterials
    Ceramics
    Composite Materials
    Polymers
Keyword
    Application
    Biological
    Calcium
    Evaluation
    Modified
    Nanoparticles
    Phosphate
    Polydimethylsiloxane
    Potential
    Spine
    Surgery
Abstract (in english)
   The biological properties of a composite made of polydimethylsiloxane matrix and two kinds of calcium phosphate nanoparticles (hydroxyapatite, beta tricalcium phosphate) were tested by means of in vitro and in vivo investigations. Chemical and phase analyses of the nanoparticles were performed. The effects of different volume fractions of nanoparticles were investigated. Human osteoblast-like cell cultures (MG 63) demonstrated that the addition of 5-15 vol.% of nanoparticles had a significantly positive effect on osteoblast viability, and that high concentration did not support cell proliferation. The highest rates of osteointegration in pig bone were attained for implants modified by 15 vol.% hydroxyapatite and more intensive formation of new bone tissue was observed. Our study indicates that hydroxyapatite probably better imitates the composition and structure of the mineral phase of real bone.
Contributor
    AV ČR Brno, Ústav struktury minerálů a hornin
Contributor code
    AV ČR, ÚSMH
Source format
    U
Import date
    24. 10. 2014